Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease

Table 3

Brief summary of other NRs in IBD.

NRs	Study type	Functions and effects	Ref.
Nur77	Nur77 KO mice; Agonist: cytosporone B	Nur Nur77 acts as a negative regulator of NF-κB by directly interacting with TRAF6	[106]
	Nur77 KO mice	Nur77 inhibits inflammatory status of both macrophages and gut epithelial cells	[107]
LRH-1	LRH-1 heterozygous mice; Epithelium-specific LRH-1-deficient mice	LRH-1 regulates intestinal immunity by mediating glucocorticoid synthesis in enterocytes	[108]
	Murine organoids; Epithelium-specific LRH-1-deficient mice	LRH-1 maintains epithelial integrity and viability; prevents crypt death and injury	[109]
LXR	LXR KO mice; Agonist: GW3965	LXR accelerates weight recovery and inhibits inflammatory mediators production	[110]
CAR	Agonist: TCPOBOP; CAR KO mice	CAR promotes intestinal epithelial migration and wound healing	[111]
HNF4α	Intestine-specific HNF4αKO mice	HNF4α preserves mucin barrier and increases intestinal permeability	[112, 113]
	HNF4α knockdown	HNF4α modifies oxidative stress, inflammation, and lipoprotein assembly	[114]
NR2F6	NR2F6 KO mice	NR2F6 binds to the Muc2 promoter and transactivates Muc2 expression, alters intestinal permeability, and protects against colitis	[115]

NRs, nuclear receptors; KO, knockout; LRH-1, liver receptor homolog-1; CAR, constitutive androstane receptor; LXR, liver X receptor; HNF4a, hepatocyte nuclear factor 4alpha.