Interleukin-12p35 Deficiency Reverses the Th1/Th2 Imbalance, Aggravates the Th17/Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-/- Mice
Effect of IL-12p35 deficiency on the activity of Th17 and Treg. (a) The frequency of Th17 and Treg in ApoE-/- mice and ApoE-/- IL-12p35-/- mice was measured by flow cytometry; for each group. (b) The serum IL-17 and IL-10 levels were detected by ELISA; for each group. (c, d) The mRNA levels of RORγT, IL-17, IL-6, TNF-α, Foxp3, and IL-10 in the spleens and aortas of these two groups were analyzed by RT-qPCR. ApoE KO = ApoE-/-, DKO = ApoE-/- IL-12p35-/-; for each group. vs. the ApoE-/-group.