Research Article

Interleukin-12p35 Deficiency Reverses the Th1/Th2 Imbalance, Aggravates the Th17/Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-/- Mice

Figure 5

rIL-35 ameliorates the development of atherosclerosis. The atherosclerotic plaque area of (a) aortic trees (10x) and (b) aortic roots (10x) in these two groups was detected by oil red O staining. The aortic roots of (c) α-SMA-positive area (20x), (d) collagen-positive area (20x), (e) CD4+ T lymphocyte (40x), and (f) macrophages (40x) were measured in the two groups. ApoE KO = ApoE-/-, DKO = ApoE-/- IL-12p35-/-; for each group. vs. the ApoE-/- group.