Inflammasome Genes’ Polymorphisms in Egyptian Chronic Hepatitis C Patients: Influence on Vulnerability to Infection and Response to Treatment
Table 4
Relation of allele and genotype frequencies of SNPs with the IFN response.
Gene
SNP ID
SVR (%)
NR (%)
OR
95% CI
value
NLRP3
rs1539019
AA
19 (22.1%)
41 (35.7%)
1.95
1-3.7
0.04
AC
56 (65.1%)
64 (55.7%)
0.67
0.38-1.2
0.18
CC
11 (12.8%)
10 (8.7%)
0.65
0.26-1.6
0.35
A
94 (54.7%)
146 (63.5%)
1.44
0.96-2.16
0.07
C
78 (45.4%)
84 (36.5%)
0.69
0.46-1.04
0.07
rs35829419
CC
68 (79.1%)
105 (91.3%)
2.78
1.2-6.4
0.016
CA
17 (19.8%)
10 (8.7%)
0.39
0.17-0.9
0.026
AA
1 (1.2%)
0
0.25
0.01-6.1
0.39
C
153 (89%)
220 (95.7%)
2.73
1.24-6
0.013
A
19 (11%)
10 (4.3%)
0.37
0.17-0.81
0.013
rs10754558
GG
19 (26.4%)
20 (26.7%)
1.01
0.49-2.1
0.97
GC
38 (52.8%)
40 (53.3%)
1.02
0.53-1.9
0.95
CC
15 (20.8%)
15 (20%)
0.95
0.43-2.1
0.9
C
68 (47.2%)
70 (46.7%)
0.98
0.62-1.5
0.92
G
76 (52.8%)
80 (53.3%)
1.02
0.65-1.6
0.92
IL-1β
rs1143629
AA
36 (41.9%)
50 (43.5%)
1.07
0.61-1.88
0.82
AG
37 (43.0%)
47 (40.9%)
0.92
0.52-1.61
0.76
GG
13 (15.1%)
18 (15.7%)
1.04
0.48-2.26
0.92
A
109 (63.4%)
147 (63.9%)
1.02
0.68-1.54
0.91
G
63 (36.6%)
83 (36.1%)
0.98
0.65-1.47
0.91
rs1143634
GG
44 (51.2%)
53 (46.1%)
0.82
0.47-1.43
0.48
GA
36 (41.9%)
49 (42.6%)
1.03
0.59-1.82
0.92
AA
6 (7.0%)
13 (11.3%)
1.7
0.62-4.67
0.3
G
124 (72.1%)
155 (67.4%)
0.8
0.52-1.23
0.31
A
48 (27.9%)
75 (32.6%)
1.25
0.81-1.93
0.31
IL-18
rs187238
CC
48 (55.8%)
54 (47.0%)
0.7
0.4-1.23
0.21
CG
37 (43.0%)
57 (49.6%)
1.3
0.74-2.28
0.36
GG
1 (1.2%)
4 (3.5%)
3.06
0.33-28
0.32
C
133 (77.3%)
165 (71.7%)
0.74
0.47-1.18
0.21
G
39 (22.7%)
65 (28.3%)
1.34
0.85-2.12
0.21
rs1946518
GG
30 (34.9%)
40 (34.8%)
1
0.55-1.79
0.99
GT
41 (47.7%)
51 (44.3%)
0.87
0.5-1.53
0.64
TT
15 (17.4%)
24 (20.9%)
1.25
0.61-2.55
0.54
G
101 (58.7%)
131 (57%)
0.93
0.62-1.39
0.72
T
71 (41.3%)
99 (43%)
0.93
0.62-1.39
0.72
CARD8
rs6509365
GG
12 (14.0%)
17 (14.8%)
1.07
0.48-2.38
0.89
AG
38 (44.2%)
60 (52.2%)
1.38
0.79-2.42
0.26
AA
36 (41.9%)
38 (33.0%)
0.69
0.38-1.22
0.2
A
110 (64%)
136 (59.1%)
0.82
0.54-1.23
0.33
G
62 (36%)
94 (40.9%)
1.23
0.82-1.84
0.33
rs2043211
AA
40 (46.5%)
42 (36.5%)
0.66
0.37-1.17
0.15
AT
40 (46.5%)
54 (47.0%)
1.02
0.58-1.78
0.95
TT
6 (7.0%)
19 (16.5%)
2.64
1-6.92
0.048
A
120 (69.8%)
138 (60%)
0.65
0.43-0.99
0.04
T
52 (30.2%)
92 (40%)
1.54
1.01-2.34
0.04
IFN = interferon; OR = odds ratio; CI = confidence interval; SVR = sustained virological response; NR = nonresponder. All SNPs were characterized for 201 HCV patients (except rs10754558 is performed only on 147 patients) and 95 controls. Significant values are in italics. is considered significant.
