Long Pentraxin 3 as a Broader Biomarker for Multiple Risk Factors in End-Stage Renal Disease: Association with All-Cause Mortality
Table 2
Circulating levels of inflammatory markers, lipid profile, adipokines, and cardiac and renal fibrosis biomarkers in controls and end-stage renal disease patients.
Controls ()
ESRD patients ()
Inflammatory markers
PTX3 (ng/mL)
0.62 [0.50–0.74]
1.40 [0.96–2.06]
<0.001
hsCRP (mg/dL)
0.10 [0.04–0.20]
0.36 [0.18–0.77]
<0.001
IL-6 (pg/mL)
1.04 [0.68–1.54]
4.09 [2.64–7.47]
<0.001
TNF-α (pg/mL)
0.83 [0.71–1.09]
3.31 [2.65–4.45]
<0.001
Lipid profile and adipokines
Total cholesterol (mg/dL)
204.0 [188.2–221.2]
159.5 [133.8–188.0]
<0.001
Triglycerides (mg/dL)
90.0 [71.2–107.5]
133.0 [97.5–183.2]
<0.001
HDL-C (mg/dL)
52.6 [44.7–65.4]
45.2 [38.9–55.1]
0.013
LDL-C (mg/dL)
122.2 [104.4–137.9]
79.6 [64.5–104.5]
<0.001
oxLDL (U/L)
67.5 [55.4–73.5]
44.4 [34.1–56.4]
<0.001
oxLDL/LDL-C ratio
0.055 [0.049–0.064]
0.054 [0.046–0.067]
0.940
Adiponectin (μg/mL)
5.75 [3.02–8.35]
12.32 [7.86–20.00]
<0.001
Leptin (ng/mL)
9.34 [4.94–21.61]
13.77 [4.82–38.88]
0.180b
Cardiac marker
NT-proBNP (ng/mL)
N.D. [N.D.–0.25]a
13.57 [8.21–25.23]
<0.001c
Renal fibrosis marker
TIMP-1 (ng/mL)
243.0 [212.2–325.0]
537.0 [467.8–627.2]
<0.001
Data are presented as median (interquartile range). aLevels of NT-proBNP were below the detection limit of the technique for a total of 12 control samples. b and c after adjustment for confounding factors. ESRD: end-stage renal disease; PTX3: pentraxin 3; hsCRP: high-sensitivity C-reactive protein; IL-6: interleukin-6; TNF-α: tumor necrosis factor-alpha; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; oxLDL: oxidized LDL; NT-proBNP: N-terminal pro-B-type natriuretic peptide; TIMP-1: tissue inhibitor of metalloproteinase-1.
