Mediators of Inflammation
Volume 2019, Article ID 4182015, 14 pages
https://doi.org/10.1155/2019/4182015
Interleukin-4 Promotes Myogenesis and Boosts Myocyte Insulin Efficacy
1Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan
2Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan
3Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
4Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan
5Department of Nursing, College of Nursing, Hungkuang University, Taichung, Taiwan
Correspondence should be addressed to Ming-Yuh Shiau; wt.ude.kh.esirnus@gnim
Received 10 April 2019; Revised 30 June 2019; Accepted 18 July 2019; Published 11 November 2019
Academic Editor: Cristina Contreras
Copyright © 2019 Yih-Hsin Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- K. Polonsky and S. Lilly, “Lilly Lecture 1994. The beta-cell in diabetes: from molecular genetics to clinical research,” Diabetes, vol. 44, no. 6, pp. 705–717, 1995. View at Publisher · View at Google Scholar
- G. S. Hotamisligil, N. S. Shargill, and B. M. Spiegelman, “Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance,” Science, vol. 259, no. 5091, pp. 87–91, 1993. View at Publisher · View at Google Scholar · View at Scopus
- J. C. Pickup, M. B. Mattock, G. D. Chusney, and D. Burt, “NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X,” Diabetologia, vol. 40, no. 11, pp. 1286–1292, 1997. View at Publisher · View at Google Scholar · View at Scopus
- J. C. Pickup and M. A. Crook, “Is type II diabetes mellitus a disease of the innate immune system?” Diabetologia, vol. 41, no. 10, pp. 1241–1248, 1998. View at Publisher · View at Google Scholar · View at Scopus
- K. E. Wellen and G. S. Hotamisligil, “Obesity-induced inflammatory changes in adipose tissue,” Journal of Clinical Investigation, vol. 112, no. 12, pp. 1785–1788, 2003. View at Publisher · View at Google Scholar · View at Scopus
- P. Z. Zimmet and K. G. M. M. Alberti, “The changing face of macrovascular disease in non-insulin-dependent diabetes mellitus: an epidemic in progress,” Lancet, vol. 350, pp. S1–S4, 1997. View at Publisher · View at Google Scholar
- C. H. Lang, C. Dobrescu, and G. J. Bagby, “Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output,” Endocrinology, vol. 130, no. 1, pp. 43–52, 1992. View at Publisher · View at Google Scholar · View at Scopus
- J. M. Stouthard, R. P. Oude Elferink, and H. P. Sauerwein, “Interleukin-6 enhances glucose transport in 3T3-L1 adipocytes,” Biochemical and Biophysical Research Communications, vol. 220, pp. 241–245, 1996. View at Publisher · View at Google Scholar · View at Scopus
- K. Nelms, A. D. Keegan, J. Zamorano, J. J. Ryan, and W. E. Paul, “The IL-4 receptor: signaling mechanisms and biologic functions,” Annual Review of Immunology, vol. 17, no. 1, pp. 701–738, 1999. View at Publisher · View at Google Scholar · View at Scopus
- K. T. Ho, M. Y. Shiau, Y. H. Chang, C. M. Chen, S. C. Yang, and C. N. Huang, “Association of interleukin-4 promoter polymorphisms in Taiwanese patients with type 2 diabetes mellitus,” Metabolism, vol. 59, no. 12, pp. 1717–1722, 2010. View at Publisher · View at Google Scholar · View at Scopus
- Y. H. Chang, C. N. Huang, and M. Y. Shiau, “Association of IL-4 receptor gene polymorphisms with high density lipoprotein cholesterol,” Cytokine, vol. 59, no. 2, pp. 309–312, 2012. View at Publisher · View at Google Scholar · View at Scopus
- Y. H. Chang, K. T. Ho, S. H. Lu, C. N. Huang, and M. Y. Shiau, “Regulation of glucose/lipid metabolism and insulin sensitivity by interleukin-4,” International Journal of Obesity, vol. 36, no. 7, pp. 993–998, 2012. View at Publisher · View at Google Scholar · View at Scopus
- M.-Y. Shiau, P.-S. Lee, Y.-J. Huang et al., “Role of PARL-PINK1-Parkin pathway in adipocyte differentiation,” Metabolism, vol. 72, pp. 1–17, 2017. View at Publisher · View at Google Scholar · View at Scopus
- C. H. Tsao, M. Y. Shiau, P. H. Chuang, Y. H. Chang, and J. Hwang, “Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis,” Journal of Lipid Research, vol. 55, no. 3, pp. 385–397, 2014. View at Publisher · View at Google Scholar · View at Scopus
- M. Y. Shiau, H. F. Lu, Y. H. Chang, Y. C. Chiu, and Y. L. Shih, “Characterization of proteins regulated by interleukin-4 in 3T3-L1 adipocytes,” SpringerPlus, vol. 4, no. 1, p. 242, 2015. View at Publisher · View at Google Scholar · View at Scopus
- A. Guilherme, J. V. Virbasius, V. Puri, and M. P. Czech, “Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes,” Nature Reviews Molecular Cell Biology, vol. 9, no. 5, pp. 367–377, 2008. View at Publisher · View at Google Scholar · View at Scopus
- A. Chawla, K. D. Nguyen, and Y. P. Goh, “Macrophage-mediated inflammation in metabolic disease,” Nature Reviews Immunology, vol. 11, no. 11, pp. 738–749, 2011. View at Publisher · View at Google Scholar · View at Scopus
- C.-P. Yang, M.-Y. Shiau, Y.-R. Lai et al., “Interleukin-4 boosts insulin-induced energy deposits by enhancing glucose uptake and lipogenesis in hepatocytes,” Oxidative Medicine and Cellular Longevity, vol. 2018, Article ID 6923187, 15 pages, 2018. View at Publisher · View at Google Scholar · View at Scopus
- V. Horsley, K. M. Jansen, S. T. Mills, and G. K. Pavlath, “IL-4 acts as a myoblast recruitment factor during mammalian muscle growth,” Cell, vol. 113, no. 4, pp. 483–494, 2003. View at Publisher · View at Google Scholar · View at Scopus
- J. E. Heredia, L. Mukundan, F. M. Chen et al., “Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration,” Cell, vol. 153, no. 2, pp. 376–388, 2013. View at Publisher · View at Google Scholar · View at Scopus
- J. D. Knight and R. Kothary, “The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis,” Skeletal Muscle, vol. 1, no. 1, p. 29, 2011. View at Publisher · View at Google Scholar · View at Scopus
- B. Blaauw, C. Mammucari, L. Toniolo et al., “Akt activation prevents the force drop induced by eccentric contractions in dystrophin-deficient skeletal muscle,” Human Molecular Genetics, vol. 17, no. 23, pp. 3686–3696, 2008. View at Publisher · View at Google Scholar · View at Scopus
- S. S. Moon, “Low skeletal muscle mass is associated with insulin resistance, diabetes, and metabolic syndrome in the Korean population: the Korea National Health and nutrition examination survey (KNHANES) 2009-2010,” Endocrine Journal, vol. 61, no. 1, pp. 61–70, 2014. View at Publisher · View at Google Scholar · View at Scopus
- Y. Rolland, S. Czerwinski, G. A. van Kan et al., “Sarcopenia: Its assessment, etiology, pathogenesis, consequences and future perspectives,” The Journal of Nutrition, Health & Aging, vol. 12, no. 7, pp. 433–450, 2008. View at Publisher · View at Google Scholar · View at Scopus
- N. Carbo, S. Busquets, M. van Royen, B. Alvarez, F. J. Lopez-Soriano, and J. M. Argilés, “TNF-α is involved in activating DNA fragmentation in skeletal muscle,” British Journal of Cancer, vol. 86, no. 6, pp. 1012–1016, 2002. View at Publisher · View at Google Scholar · View at Scopus
- C. Garcia-Martinez, N. Agell, M. Llovera, F. J. Lopez-Soriano, and J. M. Argiles, “Tumour necrosis factor-α increases the ubiquitinization of rat skeletal muscle proteins,” FEBS Letters, vol. 323, no. 3, pp. 211–214, 1993. View at Publisher · View at Google Scholar · View at Scopus
- K. J. Ladner, M. A. Caligiuri, and D. C. Guttridge, “Tumor necrosis factor-regulated biphasic activation of NF-κB is required for cytokine-induced loss of skeletal muscle gene products,” The Journal of Biological Chemistry, vol. 278, no. 4, pp. 2294–2303, 2003. View at Publisher · View at Google Scholar · View at Scopus
- R. C. Langen, A. M. Schols, M. C. Kelders, E. F. Wouters, and Y. M. Janssen-Heininger, “Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-κB,” The FASEB Journal, vol. 15, no. 7, pp. 1169–1180, 2001. View at Publisher · View at Google Scholar · View at Scopus
- J. M. Argiles and F. J. Lopez-Soriano, “The role of cytokines in cancer cachexia,” Medicinal Research Reviews, vol. 19, no. 3, pp. 223–248, 1999. View at Publisher · View at Google Scholar
- M. Sandri, C. Sandri, A. Gilbert et al., “Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy,” Cell, vol. 117, no. 3, pp. 399–412, 2004. View at Publisher · View at Google Scholar · View at Scopus
- T. N. Stitt, D. Drujan, B. A. Clarke et al., “The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors,” Molecular Cell, vol. 14, no. 3, pp. 395–403, 2004. View at Publisher · View at Google Scholar · View at Scopus
- K. Walsh, “Adipokines, myokines and cardiovascular disease,” Circulation Journal, vol. 73, no. 1, pp. 13–18, 2009. View at Publisher · View at Google Scholar · View at Scopus
- E. Marzetti, C. S. Carter, S. E. Wohlgemuth et al., “Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction,” Mechanisms of Ageing and Development, vol. 130, no. 4, pp. 272–280, 2009. View at Publisher · View at Google Scholar · View at Scopus
- J. J. Senn, P. J. Klover, I. A. Nowak, and R. A. Mooney, “Interleukin-6 induces cellular insulin resistance in hepatocytes,” Diabetes, vol. 51, no. 12, pp. 3391–3399, 2002. View at Publisher · View at Google Scholar · View at Scopus
- A. A. te Velde, R. J. Huijbens, K. Heije, J. E. de Vries, and C. G. Figdor, “Interleukin-4 (IL-4) inhibits secretion of IL-1 beta, tumor necrosis factor alpha, and IL-6 by human monocytes,” Blood, vol. 76, no. 7, pp. 1392–1397, 1990. View at Google Scholar
- R. Nistala and C. S. Stump, “Skeletal muscle insulin resistance is fundamental to the cardiometabolic syndrome,” Journal of the Cardiometabolic Syndrome, vol. 1, no. 1, pp. 47–52, 2006. View at Publisher · View at Google Scholar · View at Scopus
- C. Tsigos, D. A. Papanicolaou, I. Kyrou, R. Defensor, C. S. Mitsiadia, and G. P. Chrousos, “Dose-dependent effects of recombinant human interleukin-6 on glucose regulation,” The Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 12, pp. 4167–4170, 1997. View at Publisher · View at Google Scholar · View at Scopus
- M. G. V. Heiden, D. R. Plas, J. C. Rathmell, C. J. Fox, M. H. Harris, and C. B. Thompson, “Growth factors can influence cell growth and survival through effects on glucose metabolism,” Molecular and Cellular Biology, vol. 21, no. 17, pp. 5899–5912, 2001. View at Publisher · View at Google Scholar · View at Scopus
- S. Kir, S. A. Beddow, V. T. Samuel et al., “FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis,” Science, vol. 331, no. 6024, pp. 1621–1624, 2011. View at Publisher · View at Google Scholar · View at Scopus
- C. Castaño, S. Kalko, A. Novials, and M. Párrizas, “Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 48, pp. 12158–12163, 2018. View at Publisher · View at Google Scholar · View at Scopus
- F. Szekeres, A. Chadt, R. Z. Tom et al., “The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism,” American Journal of Physiology. Endocrinology and Metabolism, vol. 303, no. 4, pp. E524–E533, 2012. View at Publisher · View at Google Scholar · View at Scopus
- G. Daniele, R. G. Mendoza, D. Winnier et al., “The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus,” Acta Diabetologica, vol. 51, no. 1, pp. 123–131, 2014. View at Publisher · View at Google Scholar · View at Scopus
- S. W. Lee, Y. S. Hong, C. M. Chun et al., “Anti-inflammatory effects of IL-4 and IL-10 on human polymorphonuclear leukocytes,” Journal of Korean Medical Science, vol. 17, no. 1, pp. 7–14, 2002. View at Publisher · View at Google Scholar · View at Scopus
- N. Mito, T. Hosoda, C. Kato, and K. Sato, “Change of cytokine balance in diet-induced obese mice,” Metabolism, vol. 49, no. 10, pp. 1295–1300, 2000. View at Publisher · View at Google Scholar · View at Scopus
- S. E. Borst, C. F. Conover, and G. J. Bagby, “Association of resistin with visceral fat and muscle insulin resistance,” Cytokine, vol. 32, no. 1, pp. 39–44, 2005. View at Publisher · View at Google Scholar · View at Scopus
- K. Kang, S. M. Reilly, V. Karabacak et al., “Adipocyte-derived Th2 cytokines and myeloid PPARδ regulate macrophage polarization and insulin sensitivity,” Cell Metabolism, vol. 7, no. 6, pp. 485–495, 2008. View at Publisher · View at Google Scholar · View at Scopus
- M.-Y. Shiau, P.-H. Chuang, C.-P. Yang et al., “Mechanism of interleukin-4 reducing lipid deposit by regulating hormone-sensitive lipase,” Scientific Reports, vol. 9, no. 1, Article ID 11974, p. 11, 2019. View at Publisher · View at Google Scholar
- R. R. Ricardo-Gonzalez, A. R. Eagle, J. I. Odegaard et al., “IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 52, pp. 22617–22622, 2010. View at Publisher · View at Google Scholar · View at Scopus