HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1

Figure 6

TGF-β1 content in serum samples from NDs and patients with CIN-1 and their correlation with the content of CD73 in their cervical samples. The content of TGF-β1 in serum samples derived from NDs and from CIN-1 patients positive for HPV-16, HPV-16+CI, and HPV-16neg is shown (a). Data are representative of three independent experiments, and the are shown. indicates significant difference () in the TGF-β1 concentration related to that of NDs. A positive () correlation between TGF-β1 and TED values of CD73 is shown for ND free of HPV infection (0.5764, ) (b) and for CIN-1 patients (0.695, ) (c). The contents of TGF-β1 and CD73 are indicated in samples from CIN-1 patients positive for HPV-16 (HPV-16, black diamonds), patients with coinfection with HPV-16 and other HPV types (HPV-16+CI, black and white diamonds), and CIN-1 patients negative for HPV-16 (HPV-16neg, white diamonds). TED: total expression density.