Lats2-Underexpressing Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate LPS-Induced Acute Lung Injury in Mice

Figure 1

Underexpression of Lats2 increases the retention of BMSCs in ALI lung tissue. (a) Immunofluorescence staining images of lungs in the MSC-shcontrol and MSC-shLats2 groups are presented from six mouse lungs obtained 3, 7, and 14 days after LPS challenge. The nuclei were stained with DAPI (blue), and the engrafted BMSCs in the lung tissue are shown as GFP-positive (green; magnification, ×400; scale  μm; white arrows, GFP-positive cells). The count of GFP-positive BMSCs in randomly selected high-power fields is presented as the deviation (). (b) Ex vivo NIR imaging of lungs in the MSC-shcontrol and MSC-shLats2 groups are shown from six mouse lungs obtained 3, 7, and 14 days after LPS challenge. .

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