Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPAR<i>γ</i>-Dependent NF-<i>κ</i>B Signaling Pathway In Vivo and In Vitro

<div>Curcumin suppressed airway mucus secretion in OVA-induced chronic asthma. (a) After 75 days of OVA sensitization and challenge, mice were sacrificed and their right lower lungs were fixed. Then, tissue sections were stained with periodic acid-Schiff (PAS) staining. The figure demonstrates a representative view (×200) from each group; (b) mucus index was calculated as the percentage of the mucus-positive area of the whole bronchial epithelium; (c) qPCR was performed to measure MUC5AC mRNA expression in the lung; (d) western blotting was obtained to analyze MUC5AC protein expression in the lung. 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Mediators of Inflammation

fig5

Figure 5

Figure 5: Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPAR<i>γ</i>-Dependent NF-<i>κ</i>B Signaling Pathway In Vivo and In Vitro 

Figure 5 | Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro 