Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro
Curcumin suppressed airway mucus secretion in OVA-induced chronic asthma. (a) After 75 days of OVA sensitization and challenge, mice were sacrificed and their right lower lungs were fixed. Then, tissue sections were stained with periodic acid-Schiff (PAS) staining. The figure demonstrates a representative view (×200) from each group; (b) mucus index was calculated as the percentage of the mucus-positive area of the whole bronchial epithelium; (c) qPCR was performed to measure MUC5AC mRNA expression in the lung; (d) western blotting was obtained to analyze MUC5AC protein expression in the lung. Each bar represents the of 10 mice. compared with control. compared with OVA. compared with OVA + Cur + shRNA-PPARγ.