Changes in Serum Cytokines May Predict Therapeutic Efficacy of Tofacitinib in Rheumatoid Arthritis

Figure 1

Changes in ESR (a), CRP (b), HAQ-DI (c), VAS (d), DAS28 (e), RF (g), and ACPA (h) in patients treated with tofacitinib. In (f), the dotted horizontal lines indicate borders between categories of DAS28: (i) high (); (ii) moderate (); (iii) low (); and (iv) patients in remission (). The -axis has six measurement time points indicated as 0, 4, 8, 12, 16, and 24 weeks after tofacitinib treatment. Abbreviations: ESR: erythrocyte sedimentation rate; CRP: C-reaction protein; HAQ-DI: Health Assessment Questionnaire-Disability Index; VAS: visual analogue scale; DAS28: disease activity score in 28 joints based on erythrocyte sedimentation rate; RF: rheumatoid factor; ACPAs: anticyclic citrullinated peptide antibodies.

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