Electronegative LDL from Rabbits Fed with Atherogenic Diet Is Highly Proinflammatory
Knockdown of lectin-type oxidized LDL receptor (LOX-1) decreased LDL(-)-induced production of IL-1β, IL-6, and TNF-α. LOX-1-, CD36-, or LacZ-knockdown (KD) cells were generated as described previously [5, 21]. Knockdown cells were incubated with PBS or 20 mg/ml LDL(-) for 24 h. Levels of IL-1β (a), IL-6 (b), and TNF-α (c) in the medium were determined. Values are the of three independent experiments. , compared to CD36- or LacZ-KD cells.
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