Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3K/AKT-eNOS Signalling in HUVECs

<div>Graphical abstract. Andrographolide (Andr) attenuates HG-induced vascular endothelial dysfunction. Andr increases the expression of P-PI3K, P-AKT, and P-eNOS that was inhibited by HG, thus suppressing the gene expression of IL-1<i>β</i>, IL-6, and TNF<i>α</i> and the expression of VEGF. Furthermore, this effect inhibits HUVECs and promotes tubule formation, consequently decreasing the levels of LDH and MDA induced by HG.</div>

Mediators of Inflammation

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Figure 5

Figure 5: Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3K/AKT-eNOS Signalling in HUVECs 

Figure 5 | Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3K/AKT-eNOS Signalling in HUVECs 