Comparison of Two Ginkgo biloba L. Extracts on Oxidative Stress and Inflammation Markers in Human Endothelial Cells

Figure 4

Ginkgo extracts inhibit NF-κB pathway in human endothelial cells. G4E (grey bars) and G24 (white bars) inhibited the NF-κB nuclear translocation induced by TNFα in a concentration-dependent fashion (a). Epigallocatechin-3-O-gallate (EGCG) 20 μM was used as reference compound (51% inhibition). At the highest concentration tested (250 μg/mL), G4E and G24 decrease phosphorylation of the NF-κB inhibitor IκBα (b). G24: acetone extract; G4E: ethanol extract.

(a)

(b)