Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways
IH attenuated CCl4- and BDL-induced liver fibrosis in mice. (a) Effect of CCl4 (BDL) and IH on serum ALT and AST and liver hydroxyproline levels. Data are presented as (, compared to the vehicle (sham) group, # compared to the CCl4 (BDL) group, and + compared to the CCl4 (BDL)+IH 10 mg/kg group). (b) Representative images of liver sections stained with H&E and Masson’s trichrome in each group (original magnification: 50x and 200x, scale bar: 100 μm).
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