RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose

Figure 2

HG activated NLRP3 inflammasome signaling in SVs. Immunoblots (a–c) and RT-PCR (d–f) showing caspase1 and IL-1β expression in each group. Caspase1 and IL-1β increased in the HG group in a concentration-dependent manner at both 12 h and 72 h, especially for 72 h. HG also caused an increase in caspase1 and IL-1β in a time-dependent manner detected by western blotting and RT-PCR (g–k). ; .

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