RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose
Effects of rapamycin on autophagy and ROS-NLRP3 inflammasome signaling in renal mesangial cells. (a) Caspase1 and IL-1β detected by immunofluorescence. (b) LC3 detected by western blot. (c) The corresponding relative gray value statistics graph of LC3B. (d, e) ROS. LC3 expression increased following rapamycin treatment compared with the NC and HG3 groups (), while the level of ROS, caspase1, and IL-1β was decreased ().
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.