Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women

Figure 1

Parameters in PCOS women with MetS or without MetS and healthy controls. (a) Serum betatrophin levels in PCOS women with MetS were significantly higher than that of PCOS women without MetS and healthy controls ( or ); (b) serum ADI concentrations, an adipocytokine-related insulin sensitivity, were markedly lower in MetS individuals than no-MetS individuals and healthy controls ( or ); (c) PCOS women with MetS have lower -values compare with PCOS women without MetS and/or healthy controls ( or ); (d) in all study populations, regression analyses of all-factor and stepwise models indicated that the main predictors of circulating ANGPTL8 were LDL-C and BMI; (e) serum ANGPTL8 concentrations decreased significantly in all study individuals and in MetS individuals; circulating ANGPTL8 levels at the stable state of clamp were still significantly higher than that of healthy individuals.

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