Mediators of Inflammation / 2019 / Article / Fig 6

Research Article

Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation

Figure 6

Vinpocetine reduces Endothelin-1 and Cox-2 mRNA expression induced by KO2. RT-qPCR was used to determine Endothelin-1 (a) and Cox-2 (b) mRNA expression. Hind paw skin was dissected three hours after intraplantar injection of KO2 (30 μg/paw) ( vs. saline group; vs. vehicle (0 mg/kg) group, one-way ANOVA followed by Tukey’s posttest; mean ± SEM).