Neuroprotective Effects of Collagen-Glycosaminoglycan Matrix Implantation following Surgical Brain Injury

Figure 2

Identification of a sustained decrease in IBA-1⁺ cells in the lesion boundary zone (LBZ) of surgical brain lesions following implantation of the collagen-glycosaminoglycan (CG) matrix. Representative microphotographs of double immunofluorescence staining of representative brain sections from the (a) sham (SHAM) group, (b) the surgery-induced lesion cavity (L) group, and (c) the CG matrix implantation following surgery-induced lesion cavity (L+CG) group on day 14 following surgical brain trauma. In the merged image of immunoreactivity, GFAP (green) represents the astrocyte marker and IBA-1 (red) indicates positive activity in cells. (d) Numbers of IBA-1⁺ cells in LBZ from the brain sections in the SHAM, L, and L+CG groups on days 7, 14, 21, and 28 after surgery. Data are presented as the . , , and vs. the SHAM group; , , and vs. the L+CG group.

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