Relation of Macrophage Migration Inhibitory Factor to Pulmonary Hemodynamics and Vascular Structure and Carbamyl-Phosphate Synthetase I Genetic Variations in Pediatric Patients with Congenital Cardiac Shunts
Photomicrographs of arteries accompanying terminal bronchioles showing severe hypertrophy of the medial layer and absence of intimal lesions. Miller’s elastic stain, objective magnification 20x for both panels. (a) 9-month-old patient with Down syndrome, with atrioventricular septal defect. Peripheral oxygen saturation was 88%, and pulmonary vascular resistance was 5.3 Wood decreasing to 1.8 during nitric oxide inhalation. Z-score transformed pulmonary artery wall thickness was 8.1, and serum MIF level was 12305 upi by chemiluminescence. (b) 4-month-old patient, with ventricular septal defect. Peripheral oxygen saturation was 95%, and pulmonary vascular resistance was 4.0 Wood decreasing to 1.3 while on nitric oxide. Pulmonary artery wall thickness was 21.2 (Z-score), and serum MIF level corresponded to 11014 upi. Both patients had AC CPSI T1405N genotype.