Relation of Macrophage Migration Inhibitory Factor to Pulmonary Hemodynamics and Vascular Structure and Carbamyl-Phosphate Synthetase I Genetic Variations in Pediatric Patients with Congenital Cardiac Shunts

Table 2

Demographic, diagnostic, and hemodynamic variables in groups defined according to the CPSI T1405N polymorphism.

	CPSI genotypes in the study
	CC ()	AC ()
Age, months	9.9 (7.2-13.6)	10.4 (7.2-15.0)	0.726†
Gender, M : F	6 : 19	7 : 9	0.326‡
Down syndrome, (%)	16 (64.0)	11 (68.8)	0.754‡
Peripheral oxygen saturation (%)	95 (94-97)	93 (91-95)	0.089†
Pulmonary-to-systemic blood flow ratio§	2.43 (2.01-2.94)	2.10 (1.65-2.66)	0.341†
High-PBF patients : high-PVR patients	18 : 7	7 : 9	0.070‡
Diagnosis			0.110ǁ
A, (%)	1 (4,0)	0 (0.0)
B, (%)	16 (64.0)	6 (37.5)
C, (%)	7 (28.0)	10 (62.5)
D, (%)	1 (4.0)	0 (0.0)
Cardiac catheterization	CC ()	AC ()
Mean pulmonary arterial pressure (mmHg)	61 (54-70)	49 (41-58)	0.031†
Mean systemic arterial pressure (mmHg)	68 (61-77)	59 (51-68)	0.107†
Pulmonary vascular resistance ()	7.98 (4.88-13.07)	4.98 (3.98-6.24)	0.039†
Systemic vascular resistance ()	14.94 (11.83-18.85)	13.56 (11.00-16.71)	0.536†
Pulmonary vascular resistance while on inhaled nitric oxide ()	5.35 (2.13-13.41)	2.98 (2.03-4.39)	0.114†

Numeric variables are expressed as geometric mean (95% CI). ^†Mann-Whitney test; ^‡Chi-square test; ^ǁlikelihood ratio; ^§estimated by echocardiography. A: pretricuspid defects, B: posttricuspid defects except for atrioventricular septal defects, C: atrioventricular septal defects, D: conotruncal defects. CPSI: carbamyl-phosphate synthetase I.