The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood

Table 4

(a) Odds ratios for death^a

Variable	Unadjusted OR (95% CI)	value	Adjusted OR^b (95% CI)	value
MMP-8	5.3 (2.1–13.4)	<0.001	4.9 (1.8–12.9)	0.001
MPO	2.8 (1.2–6.3)	0.02	2.0 (0.8–4.8)	0.12
Total MMP-9	2.2 (1.0–4.8)	0.04	1.4 (0.6–3.3)	0.41
TIMP-1	0.7 (0.3–1.5)	0.34	0.7 (0.3–1.6)	0.37
MMP-8/TIMP-1 molar ratio	3.3 (1.4–7.8)	0.005	2.8 (1.2–7.0)	0.02

^aThe results were obtained with binary logistic regression analysis. The ORs were calculated for cerebrospinal fluid concentrations above the median. ^bAdjusted for the clinical condition on admission.

(b) Odds ratios for death or severe neurological sequelae^a

Variable	Unadjusted OR (95% CI)	value	Adjusted OR^b (95% CI)	value
MMP-8	2.5 (1.3–4.6)	0.005	2.3 (1.2–4.6)	0.02
MPO	2.8 (1.4–5.2)	0.002	2.2 (1.1–4.4)	0.03
Total MMP-9	1.5 (0.8–2.7)	0.21	0.9 (0.5–1.8)	0.78
TIMP-1	0.8 (0.4–1.5)	0.51	0.8 (0.4–1.5)	0.46
MMP-8/TIMP-1 molar ratio	1.5 (0.8–2.8)	0.20	1.3 (0.6–2.5)	0.50

^aThe results were obtained with binary logistic regression analysis. The ORs were calculated for cerebrospinal fluid concentrations above the median. ^bAdjusted for the clinical condition on admission.

(c) Odds ratios for death or any neurological sequelae^a

Variable	Unadjusted OR (95% CI)	value	Adjusted OR^b (95% CI)	value
MMP-8	2.2 (1.3–3.8)	0.003	2.2 (1.2–4.0)	0.007
MPO	1.8 (1.1–3.1)	0.02	1.6 (0.9–2.8)	0.12
Total MMP-9	1.8 (1.1–3.0)	0.03	1.2 (0.7–2.2)	0.47
TIMP-1	1.4 (0.8–2.3)	0.24	1.2 (0.7–2.2)	0.45
MMP-8/TIMP-1 molar ratio	1.2 (0.7–2.0)	0.49	1.1 (0.6–2.0)	0.70

^aThe results were obtained with binary logistic regression analysis. The ORs were calculated for cerebrospinal fluid concentrations above the median. ^bAdjusted for the clinical condition on admission.