Mediators of Inflammation / 2019 / Article / Fig 2

Research Article

Protective Effects of Oridonin on Acute Liver Injury via Impeding Posttranslational Modifications of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) in the Toll-Like Receptor 4 (TLR4) Signaling Pathway

Figure 2

Effects of oridonin on gene expression profiles in LPS/D-Gal-induced ALI assayed by RNA-Seq. (a) Clustering analysis of gene expression profiles prompted by LPS/D-Gal challenge using Cytoscape software. The green part represents the genes that were upregulated by LPS/D-Gal. We focused on the target genes stimulated by LPS/D-Gal and downregulated by oridonin treatment in group d. The target genes were subjected to bioinformatics analysis. (b) GO analysis of target genes for biological processes revealed that downregulated genes were greatly enriched in immune response, chemotaxis, and inflammatory response. (c) KEGG pathway analysis of target genes showed that downregulated genes were enriched in several pathways including TLR and NOD-like receptor signaling pathways. (d) Interactions of the target genes demonstrated by KEGG pathway analysis.

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