Mediators of Inflammation / 2019 / Article / Fig 5

Research Article

Protective Effects of Oridonin on Acute Liver Injury via Impeding Posttranslational Modifications of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) in the Toll-Like Receptor 4 (TLR4) Signaling Pathway

Figure 5

Participation of MAPK plus NF-κB signaling pathways in the anti-inflammatory effect of oridonin on LPS/D-Gal-induced ALI. (a) Level of P-IκB was inhibited by oridonin in a concentration-dependent way, which was prompted by LPS/D-Gal challenge (). (b) Band intensity in western blot was quantified by ImageJ. (c) Compared to the control group, the phosphorylation levels of MAPK (ERK as well as P38) were suggestively elevated in the ALI group (). Pretreatment with oridonin significantly inhibited phosphorylation of MAPK (). (d) Band intensity in western blot was computed using ImageJ. #, ## vs. control group (A); , vs. model group (B).

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