Tissue Inhibitor of Metalloproteinase-2 Polymorphisms and Risk for HIV-Associated Neurocognitive Disorder
Table 2
Frequency distribution of TIMP-2 (-418G/C and 303G/A) polymorphism in patients with vs. without HAND and patients with HAND vs. healthy controls.
Genotypes TIMP-2 -418G/C
Patients with HAND () (%)
Patients without HAND () (%)
value
OR (95% CI)
GG
31 (62.0%)
67 (67.0%)
1
Reference
GC
15 (30.0%)
20 (20.0%)
0.30
1.55 (0.68-3.51)
CC
4 (8.0%)
13 (13.0%)
0.55
0.69 (0.20-2.32)
Alleles TIMP-2 -418G/C
Patients with HAND () (%)
Patients without HAND () (%)
value
OR (95% CI)
G
77 (77.0%)
154 (77.0%)
1
Reference
C
23 (23.0%)
46 (23.0%)
0.99
0.99 (0.55-1.78)
Genotypes TIMP-2 303G/A
Patients with HAND () (%)
Patients without HAND () (%)
value
OR (95% CI)
GG
31 (62.0%)
71 (71.0%)
1
Reference
GA
17 (34.0%)
28 (28.0%)
0.42
1.36 (0.64-2.89)
AA
2 (4.0%)
1 (1.0%)
0.24
4.58 (0.37-56.83)
Alleles TIMP-2 303G/A
Patients with HAND () (%)
Patients without HAND () (%)
value
OR (95% CI)
G
79 (79.0%)
170 (85.0%)
1
Reference
A
21 (21.0%)
30 (15.0%)
0.17
1.57 (0.83-2.30)
Genotypes TIMP-2 -418G/C
Patients with HAND () (%)
Healthy controls () (%)
value
OR (95% CI)
GG
31 (62.0%)
118 (76.6%)
1
Reference
GC
15 (30.0%)
34 (22.1%)
0.07
2.19 (0.93-5.15)
CC
4 (8.0%)
2 (1.3%)
0.03
12.55 (1.36-115.90)
Alleles TIMP-2-418G/C
Patients with HAND () (%)
Healthy controls () (%)
value
OR (95% CI)
G
77 (77.0%)
270 (87.7%)
1
Reference
C
23 (23.0%)
38 (12.3%)
0.004
2.66 (1.36-5.23)
Genotypes TIMP-2 303G/A
Patients with HAND () (%)
Healthy controls () (%)
value
OR ( 95% CI)a
GG
31 (62.0%)
106 (68.8%)
1
Reference
GA
17 (34.0%)
45 (29.2%)
0.14
1.82 (0.82-4.053)
AA
2 (4.0%)
3 (1.9%)
0.63
1.70 (0.20-14.64)
Alleles TIMP-2 303G/A
Patients with HAND () (%)
Healthy controls () (%)
value
OR (95% CI)
G
79 (79.0%)
257 (83.4%)
1
Reference
A
21 (21.0%)
51 (16.6%)
0.12
1.68 (0.88-3.23)
= total number of subjects, (%) = frequency of genotypes/alleles, age-adjusted OR (odds ratio) and 95% CI (confidence intervals) were derived from logistic regression models comparing the homozygous wild-type genotype/allele (GG genotype and G allele for TIMP-2 -418G/C and 303G/A were taken as reference) with other genotypes/alleles. Significant values () and related OR (95% CI) have been shown in bold.
