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Mediators of Inflammation
Volume 2019, Article ID 8495913, 10 pages
Review Article

The Role of Long-Chain Fatty Acids in Inflammatory Bowel Disease

1Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China
2Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China
3West China School of Medicine, Sichuan University, Chengdu, China

Correspondence should be addressed to Hu Zhang; nc.ude.ucs@uhgnahz

Received 23 August 2019; Accepted 3 October 2019; Published 3 November 2019

Academic Editor: Carla Sipert

Copyright © 2019 Chunxiang Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Inflammatory bowel disease (IBD) is a complicated disease involving multiple pathogenic factors. The complex relationships between long-chain fatty acids (LCFAs) and the morbidity of IBD drive numerous studies to unravel the underlying mechanisms. A better understanding of the role of LCFAs in IBD will substitute or boost the current IBD therapies, thereby obtaining mucosal healing. In this review, we focused on the roles of LCFAs on the important links of inflammatory regulation in IBD, including in the pathogen recognition phase and in the inflammatory resolving phase, and the effects of LCFAs on immune cells in IBD.