The Role of Long-Chain Fatty Acids in Inflammatory Bowel Disease

Table 2

Effects of LCFAs on immunity cells in IBD.

Effects of LCFAs on immune cells	The type of LCFAs	Role
Neutrophils	n-6 PUFAs	Inhibit neutrophil infiltration
	DHA and EPA	Inhibit neutrophil infiltration
	n-3 PUFAs	Avert the concomitant hurt caused by neutrophil production
Dendritic cells	n-3 PUFAs	Reduce the antigen-presenting ability of DCs
	PGE2	Promote the antigen-presenting ability of DCs
B cells	Palmitic acid and oleic acid	Reduce the immune response ability of B cells
	n-3 PUFAs	Reduce the immune response ability of B cells, promote intestinal sIgA secretion
T cells	DFO	Reduce the percentage of CD8+ cells, diminish the expression of CD69 on CD4+ T cells, and increase the count of FoxP3+ CD25+ T cells
	n-3 PUFAs	Reduce the activated cytokines of Th17 cells
	Eicosanoids	Decrease the percentage of Th17 cells