Table 3: Effects of LCFAs in the resolving phase in IBD.

Resolving phaseThe type of LCFAsRole

Neutrophil traffickingRvE1, RvD2, LXA4, and MaR1Inhabit PMN infiltration
Apoptosis and phagocytosisResolvins from n-6 and n-3 PUFAsPromote phagocytosis of macrophages, polarize macrophages towards M2 phenotype
RvD1Promote phagocytosis of apoptotic macrophages
LXA4Promote phagocytosis of apoptotic macrophages and neutrophils
RvE1Promote phagocytosis of apoptotic neutrophils
Protectin D1Promote phagocytosis of apoptotic neutrophils