Implication of IL-17 in Bone Loss and Structural Damage in Inflammatory Rheumatic Diseases

Figure 1

Summary of the in vitro effects of IL-17 on osteoblast, osteoclast, and chondrocyte differentiation. RANK-L: receptor activator of nuclear factor kappa-B ligand; RANK: receptor activator of nuclear factor kappa-B; hMSC: human mesenchymal stem cells; TIMP: tissue inhibitors of metalloproteinases; iNOS: inducible nitric oxide synthase; COX2: cyclooxygenase-2; MMP: matrix metalloproteinase; sFRP1: secreted frizzled-related protein 1; ALP: alkaline phosphatase.