Hydrogen Sulfide Attenuates High Glucose-Induced Human Retinal Pigment Epithelial Cell Inflammation by Inhibiting ROS Formation and NLRP3 Inflammasome Activation
The high glucose-induced activation of the inflammasome in ARPE-19 cells. The mRNA expression of NLRP3, ASC, and caspase-1 in ARPE-19 cells after low-glucose and high-glucose culture for 48 hours was determined by RT-PCR. (a) NLRP3 mRNA levels were relative to GAPDH. (b) ASC mRNA levels were relative to GAPDH. (c) Caspase-1 mRNA levels were relative to GAPDH. Data were presented as the error (SE) of three independent experiments. and , compared between the low-glucose and high-glucose groups (low glucose: 5.5 mM, high glucose: 25 mM).
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