Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein
High levels of collagen were found in the kidneys of the hypertensive group. (a) Picro sirius red stained renal paraffin sections (renal cortex and medulla) of nonhypertensive control (C) and of rAOGEN transgenic hypertensive (H) mice at the age of 12 weeks. Light microscopic images were taken using a Keyence microscope (BZ-9000). Yellow arrows represent the perivascular fibrosis and black arrows the interstitial fibrosis. The . (b) Analysis and quantification of total fibrosis (interstitial and perivascular) were performed on digital renal images using a Keyence BZII analyzer. Data were presented as the area of fibrosis in % of whole renal section (4 sections/animal/groups). Histology with four mice of each group.
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