Research Article
Correlation between Serum IL-35 Levels and Bone Loss in Postmenopausal Women with Rheumatoid Arthritis
Table 2
Multivariate linear regression analysis of BMD.
| Covariates | BMD | Lumbar spine (L1-L4) | Total hip | OR | 95% CI | value | OR | 95% CI | value |
| Disease characteristics | | | | | | | Disease duration | 0.010 | -0.036-0.038 | 0.096 | 0.015 | -0.033-0.035 | 0.095 | ESR | -0.037 | -0.002-0.002 | 0.075 | -0.063 | -0.001-0.002 | 0.063 | CRP | -0.113 | -0.002-0.001 | 0.315 | -0.114 | -0.002-0.001 | 0.339 | DAS28-ESR | -0.258 | -0.070-0.012 | 0.086 | -0.301 | -0.067-0.008 | 0.122 | RF | -0.162 | -0.007-0.004 | 0.065 | -0.037 | -0.005-0.0005 | 0.092 | ACPA | -0.250 | 0.000-0.000 | 0.089 | -0.300 | 0.000-0.000 | 0.097 | BTMs | | | | | | | β-CTX | -0.165 | 0.000-0.000 | 0.021 | -0.075 | 0.000-0.000 | 0.050 | ALP | 0.063 | -0.003-0.002 | 0.059 | 0.032 | -0.002-0.002 | 0.079 | 25-(OH) VitD3 | 0.134 | -0.003-0.013 | 0.082 | 0.032 | -0.003-0.011 | 0.093 | IL-35 | 0.463 | -0.009-0.033 | 0.026 | 0.254 | -0.014-0.025 | 0.025 | Medications | | | | | | | HCQ | 0.156 | -0.157-0.030 | 0.181 | 0.065 | -0.109-0.063 | 0.596 | MTX | 0.027 | -0.101-0.126 | 0.825 | 0.026 | -0.093-0.115 | 0.836 | LEF | 0.075 | -0.090-0.164 | 0.563 | 0.126 | -0.062-0.171 | 0.356 | TG | 0.074 | -0.081-0.154 | 0.534 | 0.213 | -0.016-0.199 | 0.093 |
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BMD adjusted for disease duration, ESR, CRP, DAS28-ESR, RF, ACPA, β-CTX, ALP, IL-35, 25-(OH) VitD3, and medications. Abbreviations: BMD: bone mineral density; ESR: erythrocyte sedimentation rate; CRP: C-reaction protein; DAS28-ESR: disease activity score in 28 joints based on erythrocyte sedimentation rate; RF: rheumatoid factor; ACPA: anticyclic citrullinated peptide antibodies; BTMs: bone turnover markers; β-CTX: β-isomerised carboxy-terminal cross-linking telopeptide of type I collagen; ALP: alkaline phosphatase; IL: interleukin; HCQ: hydroxychloroquine; MTX: methotrexate; LEF: leflunomide; TG: tripterygium glycosides; OR: odds ratio; CI: confidence interval.
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