Mediators of Inflammation / 2020 / Article / Fig 1

Research Article

The Effects of Targeted Temperature Management on Oxygen-Glucose Deprivation/Reperfusion-Induced Injury and DAMP Release in Murine Primary Cardiomyocytes

Figure 1

Experimental time-temperature protocol. Normothermic OGD/R-induced injury groups were maintained at 37°C for the duration of the experiment, while TTM-treated groups were cooled to 33.5°C after 1 hour exposure to OGD and maintained during the simulated reperfusion phase. Experimental samples were analyzed (a) directly after exposure to increasing duration of OGD (2-6 h) and 6 hours of simulated reperfusion (8-12 h after experimental start, respectively) or (b) directly after exposure to 6 hours OGD and 12 or 24 hours of simulated reperfusion (18 and 30 h after experimental start, respectively).

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