P2Y2 Receptor Induces L. amazonensis Infection Control in a Mechanism Dependent on Caspase-1 Activation and IL-1β Secretion
The antiparasitic effect by P2Y2R requires CASP-1 activity. (a) Schematics showing the infection and treatments. Infected peritoneal macrophages from BALB/c were treated with UTP (100 μM) (c, e) for 30 min or left untreated (b) following Z-YVAD-FMK (2 μM) (d, e). The antiparasitic effect of UTP treatment was evaluated through the “infection index” (f). Data represent of three independent experiments performed in triplicate, with pools of 3–4 animals in each experiment. relative to the untreated group (one-way analysis of variance followed by Tukey’s test).
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