Perspectives in HPV Secondary Screening and Personalized Therapy Basing on Our Understanding of HPV-Related Carcinogenesis Pathways

Figure 1

pRB role in cell cycle 1. During the G1 phase, unphosphorylated pRB forms a complex with E2F thus stopping progression to the S phase. Additionally, pRB has an inhibiting effect on p16INK4a gene promoter.