CD19⁺CD24^hiCD38^hi B Cell Dysfunction in Primary Biliary Cholangitis

Figure 5

CD19⁺CD24^hiCD38^hi B cells from PBC patients express greater amounts of IL-6 and IL-12 when stimulated with anti-BCR and CpG. PBMC were stimulated with CpG and anti-BCR for 48 h plus phorbol ester, ionomycin, and Brefeldin A (last 5 h). (a, c, e) Each representative dot plot shows the frequency of IL-6, IL-12, or TNF-α within the CD19⁺CD24^hiCD38^hi B subset from PBC or HC. (b, d, f) Cumulative frequency of IL-6-, IL-12-, or TNF-α-producing cells within the CD19⁺CD24^hiCD38^hi B subsets from PBC patients or HC subjects; .

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