IκB Kinase Inhibitor VII Modulates Sepsis-Induced Excessive Inflammation and Cardiac Dysfunction in 5/6 Nephrectomized Mice

Figure 7

Blockade of IKK decreased the CLP-mediated cardiac dysfunction in animals subjected to 5/6 nephrectomy. 5/6 nephrectomized mice subjected to sham surgery or CLP. After 1 hour of CLP, the mice were exposed with either IKK inhibitor VII (1 mg/kg I.V.) or DMSO (2%) which was used as vehicle. The cardiac activity was evaluated after 24 hours. Data shows percentages of (a) EF, (b) FCA, and (c) FS. The groups studied were 5/6 nephrectomized mice and 5/6 nephrectomized sham mice; 5/6 nephrectomized, CLP, and vehicle treated, and 5/6 nephrectomized, CLP, and IKK inhibitor VII. All the results are presented as . compared to 5/6 nephrectomized mice, CLP, or vehicle-treated group.

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