Global Transcriptional Profiling Reveals Novel Autocrine Functions of Interleukin 6 in Human Vascular Endothelial Cells

Figure 2

Number of differentially expressed genes in human endothelial cells after IL6 knockdown. The number in each circle represents the number of differentially expressed genes using a fold change of 1.5 and Benjamini-Hochberg’s estimate of the false discovery rate below 0.05. The numbers within intersections stand for mutual differentially expressed genes between the different conditions, and numbers outside intersections represent genes unique to each condition. IL6KD: IL6 knockdown vs. control (blue circle). IL6KD+sIL6R: IL6 knockdown in the presence of the soluble IL6 receptor vs. soluble IL6 receptor (green circle). sIL6R: soluble IL6 receptor vs. control (yellow circle).