Global Transcriptional Profiling Reveals Novel Autocrine Functions of Interleukin 6 in Human Vascular Endothelial Cells

Figure 6

Canonical pathways regulated by IL6 knockdown. Using Ingenuity Pathway Analysis (IPA), enriched canonical pathways after IL6 knockdown in human endothelial cells were plotted together with the differentially expressed genes within each pathway. Activated pathways () are indicated in orange, and inhibited pathways () are indicated in blue. Downregulated genes are indicated in green, while upregulated genes are indicate in red. Genes only included in one pathway are indicated by dashed lines, and genes included in more than one pathway are indicated by solid lines. Only significantly regulated pathways () are included, and only differentially regulated genes (, Benjamini-Hochberg’s estimated ) in those pathways are shown.