Systemic Effects Induced by Hyperoxia in a Preclinical Model of Intra-abdominal Sepsis

Figure 4

Brain and lung damage markers in septic, sham-septic, and healthy rats. Septic animals underwent cecal ligation and puncture (CLP), and all animals were treated for 24 h with 21% (medical air), 40%, 60%, or 100% oxygen. (a) Serum levels of neuron-specific enolase (NSE) in CLP rats ( per group); sham-septic and healthy animals had undetectable levels. (b) S100B serum levels in CLP rats ( per group); sham-septic and healthy animals had undetectable levels. (c) Semiquantitative histological total lung injury score in CLP (-10 per group), sham-septic ( per group), and healthy ( per group) rats. No significant differences were found among oxygen groups for the lung injury score. Data are box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile, and largest observation. by the Mann–Whitney test with Bonferroni correction.

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