Systemic Effects Induced by Hyperoxia in a Preclinical Model of Intra-abdominal Sepsis

Table 1

Serum IL-6 levels in healthy, sham-septic, and CLP-septic rats at the different oxygen concentrations.

	21% O2	40% O2	60% O2	100% O2
Healthy; /group	15.8^### (14.2-21.0)	19.5^### (16.2-23.0)	39.0 (29.9-42.2)	55.7 (41.9-59.8)	<0.001	<0.001
Sham-septic; /group	49.2 (44.2-54.9)	51.1 (45.7-55.7)	58.4 (51.5-65.1)	85.8 (82.3-87.8)	0.020	0.001
CLP; -10/group	399.5^##§ (328.5-454.2)	425.7^§ (413.8-472.4)	554.9^§ (516.7-570.7)	724.0 (649.9-744.0)	<0.001	<0.001

Values are expressed in pg/mL, as median (Q1-Q3). CLP: cecal ligation and puncture. value of the comparison between the four groups determined by the Kruskal-Wallis test. value of the tendency among the four groups determined by the Jonckheere-Terpstra test for ordered differences. ^# determined by the Mann–Whitney test with Bonferroni correction when compared to 100%. ^## determined by the Mann–Whitney test with Bonferroni correction when compared to 60%. ^§ determined by the Mann–Whitney test with Bonferroni correction when compared to 100%.