Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Parameters</td><td class="align_center">Range of activity</td><td class="align_center">Mean activity</td><td class="align_center">Number of patients with abnormality</td><td class="align_center">Correlation with APRI</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">Fibrotest</td><td class="align_center">0.02-0.55</td><td class="align_center">0.138</td><td class="align_center"><b>12/79 (15.2%)</b></td><td class="align_center"><span style="width: 45.6745ptpx;"><svg height="11.4912pt" id="M10" style="vertical-align:-3.23371pt" version="1.1" viewbox="-0.0498162 -8.25749 45.6745 11.4912" width="45.6745pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 297C600 402 548 454 439 454C406 454 381 453 344 444L365 522L353 528C314 514 254 479 229 455L218 414C184 403 146 388 113 365L123 331C148 346 175 358 208 367L107 -123C95 -180 77 -195 16 -207L9 -241L298 -229L304 -193L287 -192C232 -189 218 -179 229 -125L254 -3C275 -10 291 -12 312 -12C380 4 464 50 513 103C570 165 600 241 600 297ZM465 297C465 180 383 35 323 35C309 35 281 53 271 68L335 394C346 397 360 400 380 400C422 400 465 382 465 297Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.735,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.998,0)"><path d="M252 635C85 635 28 460 28 311C28 167 82 -12 250 -12C419 -12 472 166 472 312C472 457 419 635 252 635ZM248 594C314 594 335 455 335 314C335 174 318 29 252 29S165 180 165 315S181 594 248 594Z"></path></g><g transform="matrix(.013,0,0,-0.013,29.498,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,32.462,0)"><path d="M252 635C85 635 28 460 28 311C28 167 82 -12 250 -12C419 -12 472 166 472 312C472 457 419 635 252 635ZM248 594C314 594 335 455 335 314C335 174 318 29 252 29S165 180 165 315S181 594 248 594Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.962,0)"><path d="M152 515H407L439 613L433 623H115L70 303C91 310 134 322 179 322C270 322 327 264 327 174C327 100 297 45 235 45C178 45 130 84 106 106C93 117 82 120 70 112C53 99 38 76 38 61S43 36 63 20C84 2 126 -12 166 -12C226 -11 297 15 354 56C424 105 455 164 455 226C455 312 382 394 254 394C228 394 175 380 125 362L152 515Z"></path></g></svg><b>(</b><svg height="11.4912pt" id="M11" style="vertical-align:-3.23371pt" version="1.1" viewbox="-0.0498162 -8.25749 58.7232 11.4912" width="58.7232pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 297C600 402 548 454 439 454C406 454 381 453 344 444L365 522L353 528C314 514 254 479 229 455L218 414C184 403 146 388 113 365L123 331C148 346 175 358 208 367L107 -123C95 -180 77 -195 16 -207L9 -241L298 -229L304 -193L287 -192C232 -189 218 -179 229 -125L254 -3C275 -10 291 -12 312 -12C380 4 464 50 513 103C570 165 600 241 600 297ZM465 297C465 180 383 35 323 35C309 35 281 53 271 68L335 394C346 397 360 400 380 400C422 400 465 382 465 297Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.735,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.998,0)"><path d="M252 635C85 635 28 460 28 311C28 167 82 -12 250 -12C419 -12 472 166 472 312C472 457 419 635 252 635ZM248 594C314 594 335 455 335 314C335 174 318 29 252 29S165 180 165 315S181 594 248 594Z"></path></g><g transform="matrix(.013,0,0,-0.013,29.498,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,32.462,0)"><path d="M252 635C85 635 28 460 28 311C28 167 82 -12 250 -12C419 -12 472 166 472 312C472 457 419 635 252 635ZM248 594C314 594 335 455 335 314C335 174 318 29 252 29S165 180 165 315S181 594 248 594Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.962,0)"><path d="M252 635C85 635 28 460 28 311C28 167 82 -12 250 -12C419 -12 472 166 472 312C472 457 419 635 252 635ZM248 594C314 594 335 455 335 314C335 174 318 29 252 29S165 180 165 315S181 594 248 594Z"></path></g><g transform="matrix(.013,0,0,-0.013,45.462,0)"><path d="M179 359C209 485 294 542 343 567C378 584 421 597 450 603L443 641C405 636 339 624 294 609C178 570 28 456 28 243C28 84 127 -12 253 -12C385 -12 480 89 480 215C480 328 403 402 288 402C272 402 254 394 229 382L179 359ZM234 331C302 331 349 265 349 171C349 106 335 29 273 29C220 29 166 106 166 239C166 263 168 303 172 320C192 327 211 331 234 331Z"></path></g><g transform="matrix(.013,0,0,-0.013,51.962,0)"><path d="M152 515H407L439 613L433 623H115L70 303C91 310 134 322 179 322C270 322 327 264 327 174C327 100 297 45 235 45C178 45 130 84 106 106C93 117 82 120 70 112C53 99 38 76 38 61S43 36 63 20C84 2 126 -12 166 -12C226 -11 297 15 354 56C424 105 455 164 455 226C455 312 382 394 254 394C228 394 175 380 125 362L152 515Z"></path></g></svg><b>)</b></span></td></tr><tr><td class="align_left">Actitest</td><td class="align_center">0.01-0.65</td><td class="align_center">0.10</td><td class="align_center"><b>8/79 (10.12%)</b></td><td class="align_center"><span style="width: 45.6745ptpx;"><svg height="11.4912pt" id="M12" style="vertical-align:-3.23371pt" version="1.1" viewbox="-0.0498162 -8.25749 45.6745 11.4912" width="45.6745pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 297C600 402 548 454 439 454C406 454 381 453 344 444L365 522L353 528C314 514 254 479 229 455L218 414C184 403 146 388 113 365L123 331C148 346 175 358 208 367L107 -123C95 -180 77 -195 16 -207L9 -241L298 -229L304 -193L287 -192C232 -189 218 -179 229 -125L254 -3C275 -10 291 -12 312 -12C380 4 464 50 513 103C570 165 600 241 600 297ZM465 297C465 180 383 35 323 35C309 35 281 53 271 68L335 394C346 397 360 400 380 400C422 400 465 382 465 297Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.735,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.998,0)"><path d="M252 635C85 635 28 460 28 311C28 167 82 -12 250 -12C419 -12 472 166 472 312C472 457 419 635 252 635ZM248 594C314 594 335 455 335 314C335 174 318 29 252 29S165 180 165 315S181 594 248 594Z"></path></g><g transform="matrix(.013,0,0,-0.013,29.498,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,32.462,0)"><path d="M252 635C85 635 28 460 28 311C28 167 82 -12 250 -12C419 -12 472 166 472 312C472 457 419 635 252 635ZM248 594C314 594 335 455 335 314C335 174 318 29 252 29S165 180 165 315S181 594 248 594Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.962,0)"><path d="M152 515H407L439 613L433 623H115L70 303C91 310 134 322 179 322C270 322 327 264 327 174C327 100 297 45 235 45C178 45 130 84 106 106C93 117 82 120 70 112C53 99 38 76 38 61S43 36 63 20C84 2 126 -12 166 -12C226 -11 297 15 354 56C424 105 455 164 455 226C455 312 382 394 254 394C228 394 175 380 125 362L152 515Z"></path></g></svg><b>(</b><svg height="11.4912pt" id="M13" style="vertical-align:-3.23371pt" version="1.1" viewbox="-0.0498162 -8.25749 52.1988 11.4912" width="52.1988pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 297C600 402 548 454 439 454C406 454 381 453 344 444L365 522L353 528C314 514 254 479 229 455L218 414C184 403 146 388 113 365L123 331C148 346 175 358 208 367L107 -123C95 -180 77 -195 16 -207L9 -241L298 -229L304 -193L287 -192C232 -189 218 -179 229 -125L254 -3C275 -10 291 -12 312 -12C380 4 464 50 513 103C570 165 600 241 600 297ZM465 297C465 180 383 35 323 35C309 35 281 53 271 68L335 394C346 397 360 400 380 400C422 400 465 382 465 297Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.735,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.998,0)"><path d="M252 635C85 635 28 460 28 311C28 167 82 -12 250 -12C419 -12 472 166 472 312C472 457 419 635 252 635ZM248 594C314 594 335 455 335 314C335 174 318 29 252 29S165 180 165 315S181 594 248 594Z"></path></g><g transform="matrix(.013,0,0,-0.013,29.498,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,32.462,0)"><path d="M252 635C85 635 28 460 28 311C28 167 82 -12 250 -12C419 -12 472 166 472 312C472 457 419 635 252 635ZM248 594C314 594 335 455 335 314C335 174 318 29 252 29S165 180 165 315S181 594 248 594Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.962,0)"><path d="M253 635C100 635 24 509 24 420C24 314 97 231 217 231C234 231 251 236 275 248L324 274C298 154 195 47 47 21L53 -15C98 -14 184 2 223 18C365 74 471 201 471 382C471 519 398 635 253 635ZM232 595C310 595 335 485 335 387C335 365 334 340 330 313C316 307 300 300 275 300C202 300 156 374 156 460C156 525 178 595 232 595Z"></path></g><g transform="matrix(.013,0,0,-0.013,45.462,0)"><path d="M253 635C100 635 24 509 24 420C24 314 97 231 217 231C234 231 251 236 275 248L324 274C298 154 195 47 47 21L53 -15C98 -14 184 2 223 18C365 74 471 201 471 382C471 519 398 635 253 635ZM232 595C310 595 335 485 335 387C335 365 334 340 330 313C316 307 300 300 275 300C202 300 156 374 156 460C156 525 178 595 232 595Z"></path></g></svg><b>)</b></span></td></tr><tr><td class="align_left">APRI</td><td class="align_center">0.12-3.40</td><td class="align_center">0.458</td><td class="align_center"><b>6/79 (7.6%)</b></td><td class="align_center"><b>—</b></td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Correlation between parameters of fibrosis an APRI in patients with cystic fibrosis.</div>

Mediators of Inflammation

tab3

Table 3

Table 3: Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis 