Research Article
Assessment of Selected Parameters of Liver Fibrosis and Inflammation in Patients with Diagnosed Cystic Fibrosis
(a) Values of APRI, Fibrotest, and Actitest depending on the clinical picture of patients with diagnosed cystic fibrosis |
| | Number | APRI range (mean) | Fibrotest | Actitest |
| | Age | | | | | | <2 yo | 13/79 (16.5%) | 0.15-3.4 (mean: 0.33) | 0.06-0.21 (mean: 0.13) | 0.01-0.14 (mean: 0.092) | | 2-6 yo | 29/79 (36.7%) | 0.12-2.57 (mean:0.40) | 0.100-0.55 (mean: 0.16) | 0.07-0.65 (mean: 0.12) | | >6 yo | 37/79 (46.8%) | 0.06-2.15 (mean:0.22) | 0.02-0.165 (mean: 0.122) | 0.04-0.100 (mean: 0.091) | | | | | | | | Sex | | | | | | Female | 49/79 (62%) | 0.12-3.4 (mean: 0.33) | 0.02-0.041 (mean: 0.17) | 0.01-0.65 (mean:0.103) | | Male | 30/79 (38%) | 0.15-2.15 (mean: 0.298) | 0.05-0.55 (mean:0.1) | 0.04-0.49 (mean: 0.105) | | | | | | | | CFTR mutation | | | | | | delF508del/delF508del | 41/79 (51.9%) | 0.12-3.4 (mean: 0.48) | 0.02-0.16 (mean: 0.12) | 0.047-0.65 (mean: 0.11) | | delF508del/other | 32/79 (40.5%) | 0.12-2.15 (mean: 0.40) | 0.09-0.55 (mean: 0.16) | 0.01-0.11 (mean: 0.09) | | Other | 6/79 (7.6%) | 0.21-0.68 (mean: 0.40) | 0.11-0.13 (mean: 0.11) | 0.06-0.10 (mean: 0.086) | | | | | | |
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(b) Values of APRI, Fibrotest, and Actitest in relation to the clinical picture of patients with diagnosed cystic fibrosis |
| | Number | APRI range (mean) | Fibrotest | Actitest |
| | CFLD (cystic fibrosis liver disease using Debray criteria) | Yes
| 0.15-3.4 (mean: 0.52) | 0.04-0.55 (mean: 0.22) | 0.07-0.65 (mean: 0.12) | No
| 0.12-0.6 (mean: 0.32) | 0.02-0.41 (mean: 0.10) | 0.01-0.33 (mean: 0.10) | | | | | | |
| | Pancreatic insufficiency | Yes
| 0.12-3.4 (mean: 0.46) | 0.02-0.10 (mean: 0.076) | 0.01-0.14 (mean: 0.098) | No
| 0.12-0.87 (mean: 0.32) | 0.06-0.55 (mean: 0.12) | 0.07-0.65 (mean: 0.14) | | | | | | |
| | Malnutrition | Yes
| 0.12-3.4 (mean: 0.54) | 0.02-0.55 (mean: 0.14) | 0.04-0.65 (mean: 0.12) | No
| 0.12-0.59 (mean: 0.33) | 0.07-0.18 (mean: 0.13) | 0.01-0.100 (mean: 0.09) | | | | | | |
| | Symptoms from respiratory tract/recurrent respiratory tract infection | Yes
| 0.12-3.4 (mean: 0.34) | 0.02-0.170 (mean: 0.13) | 0.01-0.65 (mean: 0.10) | No
| 0.21-2.57 (mean: 0.87) | 0.10-0.55 (mean: 0.16) | 0.05-0.140 (mean: 0.11) | | | | | | |
| | Salt loss syndrome | Yes
| 0.15-2.57 (mean: 0.66) | 0.11-0.55 (mean: 0.17) | 0.07-0.65 (mean: 0.133) | No
| 0.12-3.4 (mean: 0.412) | 0.02-0.17 (mean: 0.13) | 0.01-0.10 (mean: 0.099) | | | | | | |
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