Metabolic Profiling by UPLC–Orbitrap–MS/MS of Liver from C57BL/6 Mice with DSS-Induced Inflammatory Bowel Disease

Figure 5

Metabolism network analysis of three treatment groups: (a) DSS group vs control group. (b) CA group vs control group. (c) GA group vs control group. Blue indicates downregulated metabolites, and red indicates upregulated metabolites. Metabolism pathway analysis of the four groups. The x-axis and the y-axis represent the pathway impact and enrichment, respectively. The critical pathways are framed by yellow boxes. (d) DSS vs control, 1-taurine and hypotaurine metabolism; 2-steroid hormone biosynthesis; 3-arachidonic acid metabolism; 4-tryptophan metabolism; 5-cysteine and methionine metabolism; 6-aminoacyl-tRNA biosynthesis; 7-glycine, serine and threonine metabolism; 8-retinol metabolism; 9-glutathione metabolism; 10-arginine and proline metabolism; 11-alanine, aspartate and glutamate metabolism. (e) DSS vs CA, 1-taurine and hypotaurine metabolism; 2-alanine, aspartate and glutamate metabolism; 3-glutathione metabolism; 4-arachidonic acid metabolism; 5-glycine, serine and threonine metabolism; 6-aminoacyl-tRNA biosynthesis; 7-arginine and proline metabolism; 8-cysteine and methionine metabolism. (f) DSS vs GA, 1-glutathione metabolism; 2-arachidonic acid metabolism; 3-arginine and proline metabolism; 4-alanine, aspartate and glutamate metabolism; 5-glycine, serine and threonine metabolism; 6-aminoacyl-tRNA biosynthesis; 7-taurine and hypotaurine metabolism; 8-cysteine and methionine metabolism.

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