Research Article

Inhibition of miR-17~92 Cluster Ameliorates High Glucose-Induced Podocyte Damage

Figure 6

Silence of ABCA1 abolished the effect of miR-17∼92 cluster inhibition on cell viability, apoptosis, and inflammation. The expression of ABCA1 mRNA (a) and protein (b) was examined after cotransfection with miR-17~92 antagomirs and si-ABCA1. Cell viability (c), apoptosis (d), content of IL-6 (e), and TNF-α (f) in MPC5 cells were detected through CCK-8 assay, Annexin V/PI double stain assay, and ELISA kit, respectively. , vs. the HG-treated group. #, vs. the HG+Anta-miR-17∼92 group.