Advanced Glycation End Products Induce Vascular Smooth Muscle Cell-Derived Foam Cell Formation and Transdifferentiate to a Macrophage-Like State
Effect of CML on VSMC secretion and migration. Predesigned siRNAs for negative control or RAGE were transfected to primary VSMCs at 25 nmol/l. VSMCs were used for experiments 72 h posttransfection. (a) Migration of VSMC induced by CML. Magnification ×200. (b) The level of IL-1β, IL-6, and TNF-α secreted from primary VSMCs. ;.
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