Midregional Proadrenomedullin (MRproADM) Serum Levels in Critically Ill Patients Are Associated with Short-Term and Overall Mortality during a Two-Year Follow-Up

Table 3

Correlations of MRproADM with clinical scores and biomarkers of inflammation, organ failure and endothelial dysfunction, Spearman rank correlation test.

	All patients		Sepsis		Nonsepsis
Markers of inflammation
CRP	0.487	<0.001	0.386	<0.001	0.361	0.003
Procalcitonin	0.550	<0.001	0.458	0.001	0.683	0.005
IL10	0.277	0.007	0.426	0.001	-0.054	n.s.
IL6	0.301	<0.001	0.190	n.s.	0.118	n.s.
TNFα	0.576	<0.001	0.539	0.008	0.658	0.02
Markers of organ dysfunction
Creatinine	0.628	<0.001	0.644	<0.001	0.500	<0.001
Cystatin C	0.757	<0.001	0.702	<0.001	0.688	<0.001
AST	0.002	n.s.	-0.013	n.s.	0.158	n.s.
GLDH	-0.058	n.s.	0.006	0.013	-0.061	n.s.
Bilirubin total	0.040	0.016	-0.454	n.s.	0.321	0.008
γGT	0.200	n.s.	-0.228	0.006	0.051	n.s.
PCHE	-0.499	<0.001	-0.506	<0.001	-0.515	<0.001
Prothrombin time	-0.272	<0.001	0.641	0.009	-0.408	n.s.
Albumin	-0.456	<0.001	0.644	<0.001	-0.273	n.s.
Urea	0.671	<0.001	0.702	<0.001	0.627	<0.001
Lactate	0.005	n.s.	0.177	0.042	-0.207	0.043
LDH	0.152	0.031	0.077	n.s.	0.248	0.001
NT-proBNP	0.602	<0.001	0.576	<0.001	0.445	0.0013
Fibrinogen	0.201	0.023	0.163	n.s.	0.064	n.s.
Markers of endothelial dysfunction
ADMA	0.346	<0.001	0.327	<0.001	0.424	<0.001
SDMA	0.616	<0.001	0.591	<0.001	0.609	<0.001
CTproET1	0.870	<0.001	0.812	<0.001	0.853	<0.001
Clinical scores
APACHE II	0.333	<0.001	0.242	0.007	0.316	0.014
SOFA	0.266	0.004	0.128	n.s.	0.390	0.014
SAPS2	0.460	<0.001	0.643	<0.001	0.248	n.s.

Abbreviations: γGT: gamma-glutamyl transpeptidase; ADMA: asymmetric dimethylarginine; APACHE: acute physiology and chronic health evaluation score; AST: aspartate aminotransferase; CRP: C-reactive protein; CTproET1: C-terminal proendothelin-1; GLDH: glutamate dehydrogenase; IL10: interleukin 10; IL6: interleukin 6; LDH: lactate dehydrogenase; MRproADM: midregional proadrenomedullin; NT-proBNP: N-terminal pro-B-type natriuretic peptide; PCHE: pseudocholinesterase; SAPS2: simplified acute physiology score; SDMA: symmetric dimethylarginine; SOFA: sepsis-related organ failure assessment score; TNFα: tumor necrosis factor-α.