TY - JOUR
AU - Tang, Hao-Neng
AU - Xiao, Fen
AU - Chen, Ya-Ru
AU - Zhuang, Si-Qi
AU - Guo, Yue
AU - Wu, Hui-Xuan
AU - Zhou, Hou-De
PY - 2020
DA - 2020/08/04
TI - Higher Serum Neuropeptide Y Levels Are Associated with Metabolically Unhealthy Obesity in Obese Chinese Adults: A Cross-Sectional Study
SP - 7903140
VL - 2020
AB - Objective. Neuropeptide Y (NPY), an orexigenic peptide known to cause hyperphagia, has been involved in the occurrence and development of obesity. However, differences in the distribution of serum NPY levels in obese phenotypes (including metabolically unhealthy obesity (MUO) phenotype and metabolically healthy obesity (MHO) phenotype) and the association of NPY with MUO phenotype have not been unequivocally established. We therefore determined associations of serum NPY levels with MUO phenotype in obese Chinese adults. Methods. A cross-sectional study was conducted from 400 obese adults in Hunan province, who underwent a health examination in the Second Xiangya Hospital, and 164 participants were finally enrolled in the study and divided into MHO and MUO groups. Serum NPY levels were examined; univariate and multivariate analyses as well as smooth curve fitting analyses were conducted to measure the association of NPY serum levels with the MUO phenotype. Results. Serum NPY levels were significantly elevated in the MUO group compared with the MHO group ((667.69±292.90) pg/mL vs. (478.89±145.53) pg/mL, p<0.001). A threshold and nonlinear association between serum NPY levels and MUO was found (p=0.001). When serum NPY levels exceeded the turning point (471.5 pg/mL), each 10 pg/mL increment in the NPY serum level was significantly associated with an 18% increased odds ratio of MUO phenotype (OR: 1.18, 95% CI: 1.07–1.29, p=0.0007) after adjusted for confounders. Conclusions. Higher NPY serum levels were positively correlated with MUO phenotype in obese Chinese adults.
SN - 0962-9351
UR - https://doi.org/10.1155/2020/7903140
DO - 10.1155/2020/7903140
JF - Mediators of Inflammation
PB - Hindawi
KW -
ER -