ASK1 Enhances Angiotensin II-Induced Liver Fibrosis <i>In Vitro</i> by Mediating Endoplasmic Reticulum Stress-Dependent Exosomes

<div>Expression of p-ASK1, ER stress-related proteins, and proinflammatory cytokines in activated HSC cells. LX-2 cells were treated with Ang II. (a) The protein bands of p-ASK1, ASK1, GRP78, PERK, p-PERK, and CHOP as well as (b) the corresponding protein levels are shown. (c) The ROS levels measured using flow cytometry are shown in the left panel, and quantified results for ROS generation are depicted in the right panel. ELISA methods were used to determine the expression levels of proinflammatory cytokines, IL-1<i>β</i> (d), IL-18 (e), and TNF-<i>α</i> (f). 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Mediators of Inflammation

fig2

Figure 2

Figure 2: ASK1 Enhances Angiotensin II-Induced Liver Fibrosis <i>In Vitro</i> by Mediating Endoplasmic Reticulum Stress-Dependent Exosomes 

Mediators of Inflammation

ASK1 Enhances Angiotensin II-Induced Liver Fibrosis In Vitro by Mediating Endoplasmic Reticulum Stress-Dependent Exosomes

Figure 2