Sustained Immunoparalysis in Endotoxin-Tolerized Monocytic Cells

Figure 2

Induction of innate immunotolerance in human PBMCs. PBMCs (10⁶ cells/ml) were isolated from whole blood ( individual donors) and stimulated for 18 h with 10 ng LPS/ml or PBS. Cytokine transcription (a) and secretion (b) were detected upon additional 3 h exposure to LPS or PBS (100 ng/ml). ; ; ; .

(a)

(b)